Name:ID:
Biochemistry Module
In this worksheet, we will practice describing the synthesis, structures, and
functions of proteins.
Q1:
Which of the following best explains the role of hydrogen bonds in protein structure?
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A Hydrogen bonds form within amino acids to join the carboxyl group to the amino
group.
B Hydrogen bonds form between amino acids to hold the protein in its secondarystructure shape (e.g., alpha-helix).
C Hydrogen bonds form between amino acids to hold them in a polypeptide chain.
D Hydrogen bonds form between amino acids and water molecules to contribute to
the quaternary structure of the protein.
Q2:
Proteins are complex macromolecules formed from polypeptide chains. What
monomers join to form polypeptides?
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A Glycerol
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B Lipids
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C Fatty acids
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D Simple sugars
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E Amino acids
Q3:
Which of the following best describes the primary structure of a protein?
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A The primary structure of a protein refers to the sequence of amino acids in its
polypeptide chain.
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B The primary structure of a protein is the complex 3D structure formed
when multiple polypeptides interact and combine.
C The primary structure of a protein is the 3D structure that forms due to interactions
between the R groups of amino acids.
D The primary structure of a protein is the folded structure (alpha-helix or beta-sheet)
formed by additional bonds formed in the polypeptide chain.
Q4:
Which of the following best describes the quaternary structure of a protein?
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A The quaternary structure of a protein is the 3D structure that forms due to
interactions between the R groups of amino acids.
B The quaternary structure of a protein is the folded structure (alpha-helix or betasheet) formed by additional bonds formed in the polypeptide chain.
C The quaternary structure of a protein is the complex 3D structure formed when
multiple polypeptides interact and combine.
D The quaternary structure of a protein refers to the sequence of amino acids in its
polypeptide chain.
Q5:
Which of the following best describes the secondary structure of a protein?
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A The secondary structure of a protein refers to the sequence of amino acids in its
polypeptide chain.
B The secondary structure of a protein is the folded structure (alpha-helix or betasheet) formed by additional bonds that are formed in the polypeptide chain.
C The secondary structure of a protein is the 3D structure that forms due to
interactions between the R groups of amino acids.
D The secondary structure of a protein is the complex 3D structure formed when
multiple polypeptides interact and combine.
Q6:
Which of the following best explains the structure of a polypeptide?
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A A polypeptide is a protein formed by the joining of three amino acids to a glycerol
molecule.
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B A polypeptide is a chain of amino acids joined together by carboxyl
bonds between the amino groups of each amino acid.
C A polypeptide is a chain of amino acids joined together by peptide bonds between
the carboxyl group of one and the amino group of another.
D A polypeptide is a chain of proteins joined by peptide bonds between the
hydrogens of each protein.
Q7:
Which of the following best describes the tertiary structure of a protein?
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A The tertiary structure of a protein is the folded structure (alpha-helix or beta-sheet)
formed by additional bonds that are formed in the polypeptide chain.
B The tertiary structure of a protein is the complex 3D structure formed when
multiple polypeptides interact and combine.
C The tertiary structure of a protein refers to the sequence of amino acids in its
polypeptide chain.
D The tertiary structure of a protein is the 3D structure that forms due to interactions
between the R groups of amino acids.
Q8:
The following is a list of bonds found in biological molecules:
I.
II.
III.
IV.
V.
Hydrogen
Ionic
Phosphodiester
Disulfide bridges
Glycosidic
What bonds are commonly present in the tertiary structure of proteins?
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A I only
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B I, II, and IV
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C I and IV only
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D II, III, and IV
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E I, II, and III
Q9:
Keratin is a long protein found in hair and nails, with many repeats of the
sulfur-containing amino acid cysteine. Using the table provided, determine the group
of proteins that keratin is most likely to belong to.
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A Globular
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B Fibrous
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C Conjugated
Q10:
Part of the basic structure of an amino acid is provided. Give the molecular formula of
the functional group that is missing.
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A NH+4
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B NH2
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C CH3
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D COOH
11. A peptide bond is the linkage between:
a. The carbonyl carbon of the carboxylic acid of one amino acid and the nitrogen of
the amine of THAT amino acid
b. The oxygen of the carboxylic acid of one amino acid and the carbon next to the
amine of ANOTHER amino acid
c. The carbonyl carbon of the carboxylic acid of one amino acid and the carbon NEXT
TO the amine of another amino acid
d. The carbonyl carbon of the carboxylic acid of one amino acid and the nitrogen of
the amine of ANOTHER amino acid
12. What does N-terminus refer to?
a. The end of a protein with a free carboxylic acid group
b. The first amino acid with the abbreviation ‘N’ in the protein
c. The end of a protein with a free amine group
d. A protein chain
13-Proteins are built in the following sequence:
A: two or more protein units attach to one another, or the protein
attaches to a non-protein structure
B: amino acid sequence is set
C: chain folds back on itself
D: beta pleating or spiraling occurs
answer choices
Primary: A, Secondary: B, Tertiary: C, Quaternary: D
Primary: B, Secondary: D, Tertiary: C, Quaternary: A
Primary: C, Secondary: D, Tertiary: B, Quaternary: A
Primary: D, Secondary: B, Tertiary: C, Quaternary: A
14-Which protein?
It is the most abundant protein in your body. It is the major
component of connective tissues that make up several body parts,
including tendons, ligaments, skin and muscles. It has many
important functions, including providing your skin with structure and
strengthening your bones.
15-Which letter corresponds to the tertiary protein structure?
16-give short notes on the structure of label E
17-Which letter corresponds to an beta sheet?
18-Which letter corresponds to alpha helix?
19- A new drug is developed which selectively cleaves covalent bonds between two sulfur atoms of nonadjacent amino acids in a polypeptide chain. Which level of protein structure in affected molecules
would be most directly affected by the drug?
Choose 1 answer:
A.
B.
C.
D.
Secondary structure
Tertiary structure
Primary structure
Quaternary structure
20-The image shows the amino Valine.
Identify
the R-group and identify which property this
R-group is
likely to belong?
21-Which parts of the amino acid react with
amino acid to form a peptide bond?
another