Traumatic Brain
Injury
Traumatic Brain Injury
(TBI)
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Epidemiology
of TBI
• 1-2 million Americans injured each year
Mechanisms of Injury
Contact forces
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Inertial forces
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Coup and Counter-
Coup Injuries
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Blast injury
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Cellular Response to Injury
Focal damage vs. Diffuse injury
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Acute Cellular and Neurochemical Effects of TBI
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Acute Cellular and Neurochemical Effects of TBI
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Acute Cellular and Neurochemical Effects of TBI
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Acute Cellular and Neurochemical Effects of TBI
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General Re-cap:
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Diffuse axonal injury
(DAI)
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Tau Pathology and Tangle Formation
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Relationship of neurobiology
and neurobehavior
Changes in cognition
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Changes in personality
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Lack of awareness of deficits
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Psychiatric disorders
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