Bio – patient scenario (upstream/downstream) assignment





Patient Scenario (Upstream/Downstream) Assignment




Addresses Learning Outcomes:




  • Use conversance of bioclose principles and the Or-laws Order to ask and response pertinent doubts encircling ethnical soundness and complaint
  • Analyze instruction to perceive among sick and soundnessy erection and capacitying.
  • Analyze how inner and visible factors source dissension of soundnessy assemblage capacity, redundant to complaint and disorders.








Mr. Smith is 60 years old. He was diagnosed delay prostate cancer five years ago. Over the elapsed few days, Mr. Smith has been sentiment increasingly wearied and has so been indisposition from a headache that did not accord to over-the-counter medications. He scheduled an provision delay his physician.




His physician produced a tangible criterion and recommended a battery of laboratory cupels and imaging procedures.




His lineage influence is 165/100 mmHg.  MRI reveals metastasis of prostate cancer to osseous web. Abdominal CT professions hinderance of domestic due to nodular extension of adrenal glands.




The table adown professions Reference values in the right-hand shaft. These values consider the recognized place of values for endurings delayout complaint or malady.  The nucleus shaft considers the resulting values for medical cupel results earned for Mr. Smith.




Take silence whether Mr. Smith’s values are delayin recognized limits.




Laboratory results from Mr. Smith’s relieve hospital access and medical cupels profession aftercited findings: 





Mr. Smith

Reference Values


2.6 mmol/L



7.3 g/dl

13.8 to 18.2 g/dL




Platelet Count




38 mmol/l

22-26 mmol/L

Urinary K+

70 mmol/L/24 hr

25-120 mmol/L/24 hr

Blood Glucose

460 mg/dl

64.8-104.4 mg/dL

Serum Aldosterone

1 ng/dl

 <31 ng/dL

24 hour Urinary Aldosterone

8.4 mcg/24 hr

2.3-21.0 mcg/24 hr


2.1 ng/ml/hr

0.65-5.0 ng/ml/hr

ACTH (Adrenocorticotropic Hormone)

1082 pg/ml

9-46 pg/ml


155.5 microg/dL

0-25 microg/dL












Laboratory findings, MRI and CT grown metastatic prostate adenocarcinoma, hypertension and rebellious hypokalemia due to ectopic ACTH origination. High levels of circulating cortisol sourced faithful activation of mineralocorticoid receptors resulting in hypokalemia, metabolic alkalosis and hypertension.








After balbutiation granted scenario, response the aftercited doubts:




1.  1.What are the factors of tangible criterion? Describe each factor. (See Module 1, Topic 8, Part B.2)




2.  2.Mr. Smith’s lineage influence was 160/100 mmHg.




a. How does a medical provider grasp or value lineage influence?




b.  What do the top (numerator) and depth (denominator) total average in the bioclose import?




c.  What is the beneathstanding the bulk of these two total?




d.  Is Mr. Smith’s lineage influence delayin recognized place? Explain how you concluded whether Mr. Smith’s lineage influence is/is not delayin recognized place.




e.  Discuss the practicable soundness issues anticipated for a special delay a lineage influence of 165/100 mm Hg.




3.   3.Based on the axioms granted, what laboratory cupels were produced and what samples were graspn from the enduring?  Select one of the laboratory cupels ordered for Mr. Smith and examine why Mr. Smith’s physician rule keep ordered the cupel and the instruction she rule keep expected to earn from that feature cupel.




4.   4. Analyze Mr. Smith's values




 a.Compare Mr. Smith’s values delay allusion values and evince whether Mr. Smith’s values are adown, overhead, or delayin recognized place (parallel Mr. Smith’s values delay the Allusion values) for each laboratory cupels in the consultation overhead from the relieve set of cupels. 




b. Select one of the values beyond of recognized place from the consultation overhead and examine practicable medical concerns cognate to the identified alter in Mr. Smith’s values.




5.  5.  What imaging procedures did Mr. Smith experience? Examine the distinctions and similarities among the two incongruous imaging approaches. What were the results of imaging procedures in Mr. Smith’s event?




6. Select one of the medical provisions from the CONCLUSION and DIAGNOSIS individuality overhead and determine what it averages.  Also, examine, in your own signification and inveterate on what you can gather encircling Mr. Smith’s case, how the laboratory or imaging cupels helped delay delineation a misrecord or making the speciality. In your own signification, examine how medical providers use the or-laws order to succeed to product through the criterion and speciality of a enduring.




You should transcribe a brief article addressing all five doubts and acquiesce it beneath "Assignments". Your progression accomplish depend upon the pleased, clarity and initiatoryity of responses written in your own signification. Good communication practices, including the use of rectify rhetoric, doom and condition erection, and punctuation, and nearness of close rationalistic, accomplish statement for a lot of your progression.




Cite all sources in APA format delayin your response passage as well-mannered-mannered as unmeasured citations in APA format at the end of the assignment.




Your progression for the brief article inveterate on presented scenario accomplish be inveterate on the aftercited factors:




  1. Answered all six doubts and all sub-parts of each doubt and provides rectify or close responses to each doubt—up to 60 points
  2. Student provides initiatory, elaborate responses, written in student’s own signification, professioning nearness of close rationalistic – up to 24 points
  3. Student incorporates provisions and concepts literary from assigned materials – up to 8 points
  4. Student rectifyly cites media in APA format – up to 4 points
  5. Form – rhetoric, spelling, title – up to 4 points